Clinical research studies involving St. John Health Cardiovascular Network physicians. Listed alphabetically by physician last name.
A – B – C – D – E – F – G – H – I – J – K – L – M – N – O – P – Q – R – S – T – U – V – W – X – Y – Z
A
Rabeea Aboufakher, MD
Correlation Between Carotid IMT and Atheroma by Quantitative Ultrasound Analysis and Coronary Plaque Assessed by 64-Slice Spiral Computed Tomography. Sponsor: SJHMC
Brian Akrami, MD
Immediate Success in Infrapopliteal Chronic Total Occlusions Using Excimer Laser and Atherectomy Devices: A Retrospective, Single-Center Review. Sponsor: SJHMC
Hanna Al-Makhamreh, MD
Contrast-Induced Nephropathy: Proteinuria an Indicator of Elevated Risks? Sponsor: PHMC
Ashish Awasthi, MD
Coronary Angioplasty in Nonagenarians. Sponsor: SJHMC
Kusai Aziz, MD
The Role of Plaque Characterization by IVUS (Intravascular Ultrasound) Virtual Histology and CT Angiography in Predicting Acute Cardiovascular Events and Cholesterol Level Threshold for Myocardial Infarction. Sponsor: SJHMC
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B
Peter Burke, MD
Combination of Myeloperoxidase, Brain Natriuretic and Abnormal T-Wave Alternans Test Markers for Appropriate ICD Therapy in SCDHeFT Criteria Patients. Sponsor: PHMC
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C
Gerald Cohen, MD
Assessment of Myocardial Perfusion by Contrast Echocardiography at Rest and During Adenosine Infusion (Comparison with Simultaneous Tc99m SPECT Imaging). Sponsor: SJHMC
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D
Marcoss Daccarett, MD
Myeloperoxidase Levels as a Novel Marker for Myocyte Reperfusion in Acute ST Segment Elevation Myocardial Infarction Patients Undergoing Coronary Interventions. Sponsor: PHMC
Shukri David, MD
Humanitarian Device Exemption for Jomed JOSTEN Coronary Stent Graft. Sponsor: Jostent
Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF). Sponsor: NIH, NINDS
APEX-AMI-A Multi-center, Randomized, Double-Blind, Parallel-group, Placebo- Controlled Study of Pexelizumab in Patients with Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Sponsor: Alexion Clinical Research Studies
Acute Myocardial Infarction with Hyperoxemic Therapy II (AMIHOT II). A Prospective, Multi-center, Randomized Study of Aqueous Oxygen Therapy for 90 Minutes in Anterior Acute Myocardinal Infarction Patients with Successful Reperfusion (VIA PCI) ¡Ü six hours after symptom onset. Sponsor: TherOx, Inc.
Thomas P Davis, MD and Lingareddy Devireddy, MD
JOMED JOSTENT Coronary Stent Graft for Treatment of Free Perforations (HDE #000001). Sponsor: Jomed Inc.
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F
Mouhanad Freih, MD
Rapid Assessment of Serum C-Reactive Protein, Myeloperoxiadase, Brain Natriuretic Peptide, and Troponin I in Patients Presenting with Chest Pain to the Emergency Department. Sponsor: PHMC
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G
Julius M. Gardin, MD
A Multi-Center, Randomized, Double-Blind, Parallel Arm, 12-Week Study to Evaluate the Efficacy and Safety of Ezetimibe 10 mg When Added to Atorvastatin 10 mg Versus Titration to Atorvastatin 20 mg and to 40 mg in Elderly Patients with Hypercholesterolemia at High Risk for CHD. Sponsor: Merck
AVAIL CLS/CRT: AV-Node Ablation with CLS and CRT Pacing Therapies for the Treatment of AF: Core Echocardiography Laboratory. Sponsor: Biotronik
DORADO-AC Optimized Doses of Darusentan as Compared to an Active Control in Resistant Hypertension (DAR-312 Version 1.0) August 2006. Sponsor: Gilead
DORADO-AC Optimized Doses of Darusentan as Compared to an Active Control in Resistant Hypertension (DAR-312-E Version 1.0) August 2006 (substudy). Sponsor: Gilead HF-Action: Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training (Version 08, December 2, 2003): NHLB1 Core Echocardiography Laboratory and Field Center. Sponsor: NIH/Duke Clinical Research Institute
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H
Nassim Haddad, MD
Pre-Coronary Angiogram Cystatin C Levels as Predictor of the Risk of Major Adverse Cardiac Events and Contrast-Induced Nephropathy Post Cardiac Catheterization. Sponsor: PHMC
Sohail A. Hassan, MD
Decompensation Detection Study (DECODE). Sponsor: Boston Scientific PEGASUS CRT Pacing Evaluation — Atrial Support Study in Cardiac Resynchronization Therapy. Sponsor: Guidant
Bischan Hassunizadeh, MD
Prevalence of Ventricular Asynchrony in Patients with Severe Left Ventricular Dysfunction and Normal QRS Duration as Assessed by M-Mode. Sponsor: PHMC Relationship between Myeloperoxidase and Stress Induced Myocardial Ischemia. Sponsor: PHMC
Julie Holland-Alter, RN
ACR National Cardiovascular Data Registry/Cardiac Catheterization Module. Sponsor: American College of Cardiology Foundation
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J
Dane Jefic, MD
Development of a Prospective Cardiac Sarcoidosis Registry. Sponsor: SJHMC
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K
Desikan Kamalakannan, MD
Pronto-Catheter Thrombectomy in Acute Myocardial Infarction: Retrospective Analysis of Microvascular Outcomes. Sponsor: SJHMC ST Elevation Myocardial Infarction in End-Stage Renal Disease. Sponsor: SJHMC
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L
Thomas A. LaLonde, MD
A Mulit-Center, Double-Blind, Randomized Study to Establish the Clinical Benefit and Safety of Vytorin vs. Simvastatin Monotherapy in High-Risk Subjects Presenting With Acute Coronary Syndrome — IMPROVE-IT. Sponsor: Shering-Plough Research
Early ACS. Sponsor: Schering Research Institute (Schering Co.) Horizons AMI Trial — Harmonizing Outcomes with Revascularization and Stents. Sponsor: Cardiovascular Research Foundation
JOMED Jostent SVG BARRICADE Trial: The Barrier Approach to Restenosis Restrict Intima and Curtail Adverse Events. Sponsor: Jomed
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M
Christian Machado, MD
Use of Dofetilide in the Prophylaxis of Atrial Fibrillation after Heart Surgery. Sponsor: PHMC
Medtronic SAVE PACe Study Search AV TM Extension for Promoting Atrioventricular Conduction. Sponsor: Medtonic, Inc.
ASSIST-Atrial Tachyarrhythmia Suppression Strategy in ICD Subjects Trial. Sponsor: St. Jude Medical MAVRIC VR IVD REGISTRY (Marquis/Maximo Programming Practices Registry). Sponsor: Medtronic, Inc.
Endotak Reliance G Evaluation of Handling and Electical Performance-REFLEx Study. Sponsor: Guidant
Clinical Research Evaluation of the ASSURE Device and Ventricular Tachyarrhythmia Therapies (REASSURE AV). Sponsor: Guidant
The Prevention of Myocardial Enlargement and Dilatation After Myocardial Infarction Study (MENDMI). Sponsor: Guidant
RESPONSE HF-Response of Cardiac Resynchronization Therapy Optimization with V-V Timing in Heart Failure Patients. Sponsor: St. Jude Medical
Double-Blind, Randomized, Placebo-Controlled, Multi-Center Study to Assess the Efficacy and Safety of Darbepoetin Alfa Treatment on Mortality and Morbidity in Heart Failure (HF) Subjects with Symptomatic Left Ventricular Systolic Dysfunction and Anemia. Sponsor: Amgen
Registry of Cardiac Resynchronization Therapy-U.S. RESTORE-U.S. Sponsor: Medtronic, Inc.
A Study of the Effects of GAP-486 on Ventricular Tachyarrhythmia Induction. Sponsor: Wyeth Ayerst
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N
Charles L. Nino, MD
The Assessment of the Medtronic AVE Interceptor Saphenous Vein Graft Filter System AMEthyst. Sponsor: Medtronic
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P
Luis A. Pires, MD
Advances in ICD Therapy (ACT) Registry. Sponsor: St. Jude Medical Medtronic Concerto AT Clinical Study. Sponsor: Medtronic
Multi-Center Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT). Sponsor: University of Rochester and Boston Scientific
NAVISTAR THERMOCOOL Evaluation of the Catheter with the STOCKERT 70 Radiofrequency Generator for Endocardial Ablation in Patients with Typical Atrial Flutter-Condition of Approval Study. Sponsor: Biosense Webster Predictors of Response to Cardiac Resynchronization Therapy (PROSPECT). Sponsor: Medtronic
Registry of AT/AF Episodes in the CRM Device Population: Rate Registry. Sponsor: St. Jude Medical
Response HF: Response of Cardiac Resynchronization Therapy Optimization with V-V Timing in Heart Failure Patients. Sponsor: St. Jude Medical
Resynchronization Therapy in Normal QRS (RethinQ). Sponsor: St. Jude Medical St. Jude Medical Device System Post-Approval (PAS). Sponsor: St. Jude Medical
Ventricular Automatic Capture Assessment Study (ULTRA). Sponsor: Guidant
Tachy Induction Study. Sponsor: Medtronic
Tendril FSR Model 1699T Leads. Sponsor: St. Jude Medical
Tissue Doppler Strain Sub-Study (TDI-Sub-Study) to the Multi-Center Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADITCRT). Sponsor: University of Rocherster and Guidant
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R
Khalid Rao, MD
Troponins as a Cardiovascular Risk Factor in Hemodialysis. Sponsor: PHMC
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S
Souheil Saba, MD
A Prospective, Multi-National, Multi-Center, Double-Blind, Randomized, Active- Controlled Trial to Compare the Effects of Lotrel (amlodipine/benezepril) to Benezepril and Hydrochlorothizide Combined on the Reduction of Cardiovascular Morbidity and Mortality in Patients with High Risk Hypertension: ACCOMPLISH (Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension). Sponsor: Novartis
Tiziano Scarabelli, MD
Plasma Urocortin as a Potential Clinical Marker of Sublethal Cardiac Ischemia. Sponsor: SJHMC
Mark Sierra, MD
Correlation of Angiogram Cystatin C Levels in Urine and Angiographically Established Coronary Artery Disease: Pilot Demographic Study in a Community Hospital. Sponsor: PHMC
Assessing the Prevalence of Dyssynchrony with Activity in Patients Having Low Ejection Fraction and a Negative Dyssynchrony Study at Rest. Sponsor: Guidant
Mukarram Siddiqui, MD
Connect-Clinical Evalution to Remote Notification to Reduce Time to Clinical Decision. Sponsor: Medtronic, Inc.
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Y
Hiroshi Yamasaki, MD
CardioSEAL Septal Occlusion System HDE#H990011. Sponsor: NMT Medical
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Z
Mark A. Zainea, MD
A Multi-Center, Prospective, Randomized, Double-Blind, Placebo Controlled Phase III Clinical Outcome Study to Examine the Long-Term Safety and Efficacy of Veliflapon (DG-031) in Reducing the Risk of Acute Cardiovascular Events by its Effect on Leukotrienes in African American Patients with Coronary Artery Disease and Leukotriene Gene Markers. Sponsor: deCODE genetics, Inc.
Khalid Zakariya, MD
Hypertension Management, are we Following Recommendations? Sponsor: PHMC
Jeffrey Zaks, MD
HF-ACTION: Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training. Sponsor: NIH
Investigation of the Role of Genetic Variation in the Clinical Expression of Heart Failure (Ancillary Study of HF-ACTION). Sponsor: NIH
Jamal Zarghami, MD
A Post-Approval Study of the Guidant Carotid Stent Systems and Embolic Protection Systems (Carotid RX ACCULINK/ACCUNET) Post-Approval Trial to Uncover Unanticipated or Rare Events-CAPTURE. Sponsor: Guidant
Comparison of CS-747 and Clopidogrel in Acute Coronary Syndrome Subjects who are to Undergo Percutaneous Coronary Intervention/TIMI-38. Sponsor: Eli Lilly Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST). Sponsor: NINDS, UMDNJ
Marcel Zughaib, MD
Early Glycoprotein IIb/IIIa Inhibition in Non ST-Segment Elevation Acute Coronary Syndrome: A Randomized, Placebo-Controlled Trial Evaluating the Clinical Benefits of Early Front-Loaded Eptifibatide in the Treatment of Patients with Non-ST-Segment Elevation Acute Coronary Syndrome (EARLY ACS). Sponsor: Millennium
EVENT REGISTRY: A Multi-Center Registry for the Evaluation of Drug Eluting Stents and Ischemic Events. Sponsor: Millennium
HORIZONS AMI TRIAL-Harmonizing Outcomes with Revascularization and Stents—A Dual Arm Factorial Randomized Trial in Patients with ST Segment Elevation AMI to Compare the Results of Using Either Anticoagulation with Unfractionated Heparin plus Routine IIb/IIIa Inhibition, and Primary Angiolpasty with Stent Implantation with Either a Slow Rate-Release Paclitaxel-Eluting Stent (TAXUS) or an Otherwise Indentical Uncoated Bare Metal Stent (Express). Sponsor: Boston Scientific, The Medicines Co.
Improved Reduction on Outcomes: Vytorin Efficacy International Trial: A Multicenter, Double-blind, Randomized Study to Establish the Clinical Benefit and Safety of Vytorin (ezetimibe/simvastatin) vs. Simvastatin Monotherapy in High- Risk Patients Presenting with Acute Coronary Syndrome. Sponsor: Merck/Schering A Post-Approval Study of the Guidant Acculink Stent System and Accunet Embolic Protection Systems-CAPTURE 2. Sponsor: Guidant
THE ACUITY TRIAL: A Randomized Comparison of Angiomax (Bivalirudin) versus Lovenox/Clexane (Enoxaparin) in Patients Undergoing Early Invasive Management for Acute Coronary Syndromes without ST-Segment Elevation. Sponsor: The Medicines Co.
TC WYRE-Taxes Express Stent vs. Cypher Stent. Sponsor: Boston Scientific
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